Improvement of bio-availability of poorly water soluble drugs presents one of the furthermost challenges in drug formulations. One of the most admired and commercially viable formulation approaches for this challenge is self micro emulsifying drug delivery system (SMEDDS). Hence aim of present study was to develop SMEDDS of poorly water soluble drug nimesulide by using oils: triacetin, surfactant: tween 20 and co-surfactant: iso propyl alcohol (IPA). For formulation of stable SMEDDS, micro emulsion region was identified by constructing pseudo ternary phase diagram containing different proportion of surfactant: co-surfactant, oil and water. Prepared SMEDDS was evaluated for flow properties, drug content, viscosity, pH and in-vitro dissolution study. Results showed that prepared SMEDDS passed all evaluation tests. Globule size was found to be 240 nm with polydispersity index 0.396. SMEDDS showed good flow property and drug content. From the experiment, it was clear that even after conversion of the liquid SMEDDS into the solid one there was no significant alteration in the properties of solid SMEDDS. In-vitro dissolution studies showed that there was enhancement of dissolution rate of nimesulide as compared with that of plain drug from the results it is concluded that SMEDDS is a promising approach to enhance dissolution rate of poorly water soluble model drug nimesulide
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